Pak Chung Sham(沈伯松)
Chair Professor
Office: Department of Psychiatry and Genome Research Centre, HKU
Phone: (852) 2819 9557

Research Interests

Prof. Sham is Chair Professor of Psychiatry and Co-Director of State Key Lab. His research interests are:
- Genetics and epidemiology of psychiatric disorders;
- Statistical methodology for genetic and epidemiological studies.


Selected Publications

Toulopoulou T, Zhang X, Cherny S, Dickinson D, Berman KF, Straub RE, Sham P, Weinberger DR. Polygenic risk score increases schizophrenia liability through cognition-relevant pathways. Brain. 2019 Feb 1; 142(2):471-485. 

Wang Q, Man Wu H, Yue W, Yan H, Zhang Y, Tan L, Deng W, Chen Q, Yang G, Lu T, Wang L, Zhang F, Yang J, Li K, Lv L, Tan Q, Zhang H, Ma X, Yang F, Li L, Wang C, Ma X, Zhao L, Ren H, Yu H, Wang Y, Hu X, Zhang D, Sham P, Li T; Chinese Antipsychotics Pharmacogenomics Consortium.  Effect of Damaging Rare Mutations in Synapse-Related Gene Sets on Response to Short-term Antipsychotic Medication in Chinese Patients With Schizophrenia: A Randomized Clinical Trial. JAMA Psychiatry. 2018 Dec 1; 75(12):1261-1269.

So HC, Chau CK, Chiu WT, Ho KS, Lo CP, Yim SH, Sham PC. Analysis of genome-wide association data highlights candidates for drug repositioning in psychiatry. Nat Neurosci. 2017 Oct; 20(10): 1342-1349.
Li M, Li J, Li MJ, Pan Z, Hsu JS, Liu DJ, Zhan X, Wang J, Song Y, Sham PC. Robust and rapid algorithms facilitate large-scale whole genome sequencing downstream analysis in an integrative framework. Nucleic Acids Res. 2017 May 19; 45(9): e75.
Wang Q, Cheng W, Li M, Ren H, Hu X, Deng W, Ma X, Zhao L, Wang Y, Xiang B, Wu HM, Sham PC, Feng J, Li T.  The CHRM3 gene is implicated in abnormal thalamo-orbital frontal cortex functional connectivity in first-episode treatment-naive patients with schizophrenia. Psychol Med. 2016 May; 46(7):1523-34.

Kwan JS, Li MX, Deng JE, Sham PC. FAPI: Fast and Accurate P-value Imputation for genome-wide association study. Eur J Hum Genet. 2016 May; 24(5):761-6.
Mak TS, Kwan JS, Campbell DD, Sham PC. Local True Discovery Rate Weighted Polygenic Scores Using GWAS Summary Data. Behav Genet. 2016 Jul; 46(4):573-82.
Li Q, Leung YO, Zhou I, Ho LC, Kong W, Basil P, Wei R, Lam S, Zhang X, Law AC, Chua SE, Sham PC, Wu EX, McAlonan GM. Dietary supplementation with n-3 fatty acids from weaning limits brain biochemistry and behavioural changes elicited by prenatal exposure to maternal inflammation in the mouse model. Translational Psychiatry, 2015 Sep 22; 5:e641. doi: 10.1038/tp.2015.126.
Wang Q, Li M, Yang Z, Hu X, Wu HM, Ni P, Ren H, Deng W, Li M, Ma X, Guo W, Zhao L, Wang Y, Xiang B, Lei W, Sham PC, Li T. Increased co-expression of genes harboring the damaging de novo mutations in Chinese schizophrenic patients during prenatal development. Sci Rep, 2015 Dec 15; 5:18209.
Toulopoulou T, Haren NV, Zhang XW, Sham PC, Cherny SS, Campbell DD, Picchioni M., Murray R., Boomsma DI, Pol HH, Brouwer R, Schnack H, Fan ̃an ́as L, Sauer H, Nenadic I, Weisbrod M, Cannon TD, Kahn RS. Reciprocal causation models of cognitive vs volumetric cerebral intermediate phenotypes for schizophrenia in a pan-European twin cohort. Molecular Psychiatry. 2014; doi:10.1038/mp.2014.152. 

Sham PC, Purcell SM. Statistical power and significance testing in large-scale genetic studies. Nat Rev Genet. 2014 May; 15(5):335-46. (pdf)
Wong EH, So HC, Li M, Wang Q, Butler AW, Paul B, Wu HM, Hui TC, Choi SC, So MT, Garcia-Barcelo MM, McAlonan GM, Chen EY, Cheung EF, Chan RC, Purcell SM, Cherny SS, Chen RR, Li T, Sham PC.Common variants on Xq28 conferring risk of schizophrenia in Han Chinese. Schizophr Bull. 2014 Jul; 40(4):777-86.  (pdf)  
Li MX, Kwan JSH, Bao S-Y, Yang W, Ho SL, Song Y-Q, Sham PC. (2013). Predicting Mendelian Disease-Causing Non-Synonymous Single Nucleotide Variants in Exome Sequencing Studies. Plos Genetics, 9(1). (pdf)
Li MX, Kwan JSH, Sham PC. (2012). HYST: A Hybrid Set-Based Test for Genome-wide Association Studies, with Application to Protein-Protein Interaction-Based Association Analysis. American Journal of Human Genetics, 91(3):478-488.  (pdf)
Li MX, Gui HS, Kwan JSH, Bao SY, Sham PC. (2012). A comprehensive framework for prioritizing variants in exome sequencing studies of Mendelian diseases. Nucleic Acids Research, 40(7). (pdf)
Li MX, Gui HS, Kwan JSH, and Sham PC. (2011). GATES: A Rapid and Powerful Gene-Based Association Test Using Extended Simes Procedure. Am J Hum Genet. 88(3):283-293. (pdf)
So HC., Kwan JSH.,Cherny SS., and Sham PC. (2011) Risk Prediction of Complex Diseases from Family History and Known Susceptibility Loci, with Applications for Cancer Screening. Am J Hum Genet. 88(5):548-565. (pdf)
So HC, Sham PC. (2010) A Unifying Framework for Evaluating the Predictive Power of Genetic Variants Based on the Level of Heritability Explained. PLoS Genetics, 6(12):13. (pdf)
Cheung C, Yu K, Fung G, Leung M, Wong C, Li Q, Sham PC, Chua S, McAlonan G. (2010). Autistic disorders and schizophrenia: related or remote? An anatomical likelihood estimation. PLoS One. 5(8):e12233. (pdf)
Ong KL, Tso AW, Lam KS, Cherny SS, Sham PC, Cheung BM. (2010). Using glycosylated hemoglobin to define the metabolic syndrome in United States adults.Diabetes Care. 33(8):1856-8.(pdf)
Ong KL, Li M, Tso AW, Xu A, Cherny SS, Sham PC, Tse HF, Lam TH, Cheung BM, Lam KS, Investigators of the Hong Kong Cardiovascular Risk Factor Prevalence Study. (2010). Association of genetic variants in the adiponectin gene with adiponectin level and hypertension in Hong Kong Chinese. Eur J Endocrinol.163(2):251-7. (pdf)
So HC, Fong PY, Chen RY, Hui TC, Ng MY, Cherny SS, Mak WW, Cheung EF, Chan RC, Chen EY, Li T, Sham PC. (2010). Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. Am J Med Genet B Neuropsychiatr Genet. 153B (1):103-13.(pdf)
Demjaha A, Morgan K, Morgan C, Landau S, Dean K, Reichenberg A, Sham PC, Fearon P, Hutchinson G, Jones PB, Murray RM, Dazzan P.(2009). Combining dimensional and categorical representation of psychosis: the way forward for DSM-V and ICD-11? Psychol Med. 39(12):1943-55. (pdf)
Deng MY, McAlonan GM, Cheung C, Chiu CP, Law CW, Cheung V, Sham PC, Chen EY, Chua SE. (2009). A naturalistic study of grey matter volume increase after early treatment in anti-psychotic naïve, newly diagnosed schizophrenia. Psychopharmacology (Berl). 206(3):437-46. (pdf)
Yeung JM, Sham PC, Chan AS, Cherny SS. (2008). OpenADAM: an open source genome-wide association data management system for Affymetrix SNP arrays.BMC Genomics. 9:636. (pdf)
Cheung V, Cheung C, McAlonan GM, Deng Y, Wong JG, Yip L, Tai KS, Khong PL, Sham PC, Chua SE. (2008). A diffusion tensor imaging study of structural dysconnectivity in never-medicated, first-episode schizophrenia. Psychol Med. 38(6):877-85. (pdf)
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