Raymond Chuen-Chung. Chang(鄭傳忠)

Associate Professor
Office: Rm. L1-49, Laboratory Block,Faculty of Medicine Building, HKU
Phone: (852) 2819 9127
Fax: (852) 2817 0857
Email: rccchang@hku.hk
HKU Scolars Hub

Research Interests

Dr. Chang is Associate Professor of Anatomy. His research interest is to study the molecular signaling pathways of neuronal death in neurodegenerative disease such as Alzheimer's disease. It has been demonstrated that postmortem human brain section displays activated caspases, suggesting that neuronal apoptosis occurs in Alzheimer's disease. We are the first to show that a novel double-stranded RNA-dependent protein kinase (PKR) is involved in ß-amyloid peptide-induced neuronal apoptosis. Although it is originally named as double-stranded RNA-dependent protein kinase, recent findings have shown that PKR is a stress kinase respond to different stress signals. PKR is not simply involved in neuronal apoptosis; it also plays significant roles in the highly regulated degenerative processes. A major on-going project in our laboratory is to elucidate and map out how PKR incorporates into other well-known signaling pathways (e.g. stress kinases and endoplasmic reticulum-associated stress responses) triggered by ß-amyloid peptide. In addition, we are now investigating the signaling events leading to autophagic neuronal death and synaptic degeneration. Understanding of the molecular signaling pathways will definitely pave a road for a better therapeutic strategy against neurodegenerative diseases.
With all the above basic science studies, we are able to engage in applied research in searching for neuroprotective agents from Chinese medicine to natural products. Through the collaboration with colleagues in Departments of Chemistry and Botany, we have identified several compounds that have high potentials to be neuroprotective agents. We are attempting to develop and commercialize some of the products into pharmaceutical market. We believe that prevention of neurodegeneration is better than treatment.

Selected Publications

Sy LK, Lok CN, Wang JY, Liu Y, Cheng L, Wan PK, Leung CT, Cao B, Kwong WL, Chang RCC Che CM (2016) Identification of “sarsasapogenin-aglyconed” timosaponins as novel Aß lowering modulators of amyloid precursor protein (APP) processing. Chem. Sci., In press.

Poon CH, Ho YS, Chiu K, Wong HL, Chang RCC. Sickness: From the focus on cytokines, prostaglandins, and complement factors to the perspectives of neurons. Neurosci. Biobehav. Rev. 2015, 57, 30-45.

Poon DCH, Ho YS, You R, Tse J, Chu K and Chang RCC.  PKR deficiency alters E. coli-induced sickness behaviors but does not exacerbate neuroimmune responses or bacterial load. J Neuroinflamm. 2015; 12:212.

Huang C, Ho YS, Ng OTW, Irwin MG, Chang RCC, Wong GTC. Dexmedetomidine directly increases tau phosphorylation. J Alz Dis. 2015 Jan 1; 44(3):839-50.

Ho WL, Leung Y, Cheng SSY, Lok CKM, Ho YS, Baum L, Yang X, Chiu K, Chang RCC. Investigating degeneration of the retina in young and aged tau P301L mice. Life Sci. 2015 Mar; 124:16-23.

Chang RCC, Ho YS, Wong S, Gentleman SM, Ng HK.(2014). Neuropathology of cigarette smoking. Acta Neuropathol, 127, 53-69. (pdf)

Poon DCH, Ho YS, Chiu K, Chang RCC.(2013). Cytokines: how important are they in mediating sickness? Neurosci. Biobehav. Rev., 37, 1-10(pdf)

Wong, G.T., Chang, R.C.C., Law, A.C.K. (2013) A breach in the scaffold: The possible role of cytoskeleton dysfunction in the pathogenesis of major depression. Ageing Res Rev 12(1): 67-75 (pdf)

Ho Cheung YT, Zhang NQ, Hung CHL, Lai CSW, Yu MS, So KF and Chang RCC. (2011). Temporal Relationships of autophagy and neuronal apoptosis in low molecular weight β-amyloid peptide neurotoxicity. J. Cell. Mol. Med., 15(2):244-57. (pdf)

YS, So KF and Chang RCC. (2010). Anti-aging herbal medicine – how and why can they be used in aging-associated neurodegenerative diseases? Ageing Res. Rev., 9, 354-362. (pdf)

Wuwongse S, Chang RCC., and Law ACK (2010). The putative neurodegenerative links between depression and Alzheimer’s disease. Prog. Neurobiol., 91, 362-375. (pdf)

Hung CHL, Ho YS and Chang RCC. (2010). Modulations of mitochondrial calcium as a pharmacological target for Alzheimer’s disease. Ageing Res. Rev., 9, 447-456. (pdf)

Chao J, Li H, Cheng KW, Yu MS, Chang RCC., and Wang M (2010). Protective effects of pinostilbene, a resveratrol methylated derivative, against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells. J. Nutr. Biochem, 21, 482-489. (pdf)

Ho YS, Yu MS, Yang X, So KF, Yuen WH and Chang RCC. (2010). Neuroprotective effects of polysaccharides from Wolfberry antagonize homocysteine-induced toxicity in rat cortical neurons. J. Alz. Dis., 19, 813-827. (pdf)

Cheung YT, Lau WKW, Yu MS, Lai CSW, Yeung SZ, So KF and Chang RCC. (2009). Effects of all-trans retinoic acid on human neuroblastoma SH-SY5Y as in vitro model of neurotoxicity research. NeuroToxicology, 30, 127-135. (pdf)

Chao J, Yu MS, Ho YS, Wang M and Chang RCC. (2008). Dietary oxyresveratrol prevents parkinsonian mimetic 6-hydroxydopamine neurotoxicity. Free Radic. Biol. Med., 45, 1019-1026. (pdf)

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