The epidemiology of population mental wellbeing in China. 
Ni MY*, Leung CMC, Leung GM. 
The Lancet Public Health 2020 Dec; 5(12):E631-E632 [link]

Determinants of Physical, Mental, and Social Well-Being: A Longitudinal Environment-Wide Association Study. 
Ni MY†, Yao XI†, Cheung F, et al. 
International Journal of Epidemiology 2020 Apr 1;49(2):380-389 [link

Depression and post-traumatic stress during major social unrest in Hong Kong: a ten-year prospective cohort. 
Ni MY*, Yao XI, Leung KS, et al. 
The Lancet 2020 Jan; 395(10220):273-284 [link]

Screen identifies DYRK1B network as mediator of transcription repression on damaged chromatin. 
Dong C, West KL, Tan XY, Li J, Ishibashi T, Yu CH, Sy SM, Leung JW, Huen MS. 
PNAS 2020; 117(29): 17019-17030.

The epilepsy and intellectual disability-associated protein TBC1D24 regulates the maintenance of excitatory synapses and animal behaviors.
Lin L, Lyu Q, Kwan PY, Zhao J, Fan R, Chai A, Lai CSW, Chan YS, Shen X, Lai KO*. 
PloS Genet. 2020 Jan 31; 16(1):e1008587.

Associations of Weekday-to-Weekend Sleep Differences with Academic Performance and Health-Related Outcomes in School-age Children and Youths. 
Sun W, Ling J, Zhu X, Lee TMC, Li SX. 
​Sleep Medicine Reviews. Sleep Med Rev. 2019 Aug; 46:27-53.

Factors associated with successful medication discontinuation after a randomized clinical trial of relapse prevention in first-episode psychosis: A 10-Year Follow-up.
Hui CLM, Honer W, Lee EHM, Chang WC, Chan SKW, Chen EYH. 
JAMA Psychiatry. 2019 Feb 1; 76(2):217-219. 

Promoting memory consolidation during sleep: A meta-analysis of target memory reactivation.
Hu X, Cheng L, Chiu M, & Paller KA.
Psychological Bulletin. 146(3):218-244 · November 2019  

Early-stage negative symptom trajectories and relationships with 13-year outcomes in first-episode non-affective psychosis. 
​Chang WC, Ho RWH, Tang JYM, Wong CSM, Hui CLM, Chan SKW, Lee EMH, Suen YN, Chen EYH. 
Schizophrenia Bulletin. 2019; 45:610-619.

Ten-year employment patterns of patients with first-episode schizophrenia-spectrum disorders: comparison of early intervention and standard care services. 
Chan SKW, Pang HH, Yan KK, Hui CLM, Suen YN, Chang WC, Lee EHM, Sham P, Chen EYH. 
Br J Psychiatry. 2019 Jul 9:1-7.

Polygenic risk score increases schizophrenia liability through cognition-relevant pathways.
Toulopoulou T, Zhang X, Cherny S, Dickinson D, Berman KF, Straub RE, Sham P, Weinberger DR. 
Brain. 2019 Feb 1; 142(2):471-485. 

Can fMRI discriminate between deception and false memory? A meta-  analytic comparison between deception and false memory studies.
Yu J, Tao Q, Zhang R, Chan CCH, Lee TMC. 
Neurosci Biobehav Rev. 2019 Sep; 104:43-55.

Association of an Early Intervention Service for Psychosis With Suicide Rate Among Patients With First-Episode Schizophrenia-Spectrum Disorders.
Chan SKW, Chan SWY, Pang HH, Yan KK, Hui CLM, Chang WC, Lee EHM, Chen EYH. 
JAMA Psychiatry. 2018 May 1; 75 (5):458-464.

Effect of Damaging Rare Mutations in Synapse-Related Gene Sets on Response to Short-term Antipsychotic Medication in Chinese Patients With Schizophrenia: A Randomized Clinical Trial.
Wang Q, Man Wu H, Yue W, Yan H, Zhang Y, Tan L, Deng W, Chen Q, Yang G, Lu T, Wang L, Zhang F, Yang J, Li K, Lv L, Tan Q, Zhang H, Ma X, Yang F, Li L, Wang C, Ma X, Zhao L, Ren H, Yu H, Wang Y, Hu X, Zhang D, Sham P, Li T; Chinese Antipsychotics Pharmacogenomics Consortium.  
JAMA Psychiatry. 2018 Dec 1; 75(12):1261-1269.

Suicide rates, psychiatric hospital bed numbers, and unemployment rates from 1999 to 2015: a population-based study in Hong Kong.
Lee EHM, Hui CLM, Chan PY, Chang WC, Chan SKW, Chen EYH.
Am J Psychiatry 2018;175(3):285-286 (letter to the editor)

Mutations in Hnrnpa1 cause congenital heart defects.
Yu Z, Tang PL, Wang J, Bao S, Shieh JT, Leung AW, Zhang Z, Gao F, Wong SY, Hui AL, Gao Y, Dung N, Zhang ZG, Fan Y, Zhou X, Zhang Y, Wong DS, Sham PC, Azhar A, Kwok PY, Tam PP, Lian Q, Cheah KS, Wang B, Song YQ. 
JCI Insight. 2018 Jan 25; 3(2).

Nucleolar residence of the Seckel Syndrome protein TRAIP is coupled to ribosomal DNA transcription.
Chen Y, Li J, Cao F, Lam J, Cheng CC, Yu CH, Huen MS. 
Nucleic Acids Res. 2018; 46(19): 10119-10131.

RNF169 limits 53BP1 deposition at DSBs to stimulate single-strand annealing repair.
An L, Dong C, Li J, Chen J, Yuan J, Huang J, Chan KM, Yu CH, Huen MS.
PNAS. 2018; 115(35): E8266-E8295.

Fear extinction reverses dendritic spine formation induced by fear conditioning in the mouse.
Lai CSW, Adler A, Gan WB. auditory cortex.
PNAS. 2018; 115(37):9306-9311.

Analysis of genome-wide association data highlights candidates for drug repositioning in psychiatry.
So HC, Chau CK, Chiu WT, Ho KS, Lo CP, Yim SH, Sham PC.
Nat Neurosci. 2017 Oct; 20(10):1342-1349.

Sustainability of treatment effect of a 3-year early intervention programme for first-episode psychosis.
Chang WC, Kwong VWY, Lau ESK, So HC, Wong CSM, Chan GHK, Jim OTT, Hui CLM, Chan SKW, Lee EHM, Chen EYH
Br J Psychiatry. 2017 Jul; 211(1):37-44.

Robust and rapid algorithms facilitate large-scale whole genome sequencing downstream analysis in an integrative framework.
Li M, Li J, Li MJ, Pan Z, Hsu JS, Liu DJ, Zhan X, Wang J, Song Y, Sham PC.
Nucleic Acids Res. 2017 May 19; 45(9):e75.

Dual-utility NLS drives RNF169-dependent DNA damage responses.
An L, Jiang Y, Ng HH, Man EP, Chen J, Khoo US, Gong Q, Huen MS.
Proc Natl Acad Sci U S A. 2017 Apr 4; 114(14):E2872-E2881.

Structural and Maturational Covariance in Early Childhood Brain Development.
Xiujuan Geng, Gang Li, Zhaohua Lu, Wei Gao, Li Wang, Dinggang Shen, Hongtu Zhu and John H. Gilmore.
Cerebral Cortex, March 2017;27:1795–1807

 A retinoraphe projection regulates serotonergic activity and looming-evoked defensive behaviour.
Huang L, Yuan T, Tan M, Xi Y, Hu Y, Tao Q, Zhao Z, Zheng J, Han Y, Xu F, Luo M, Sollars PJ, Pu M, Pickard GE, So KF, Ren C.
Nat Commun. 2017 Mar 31;8:14908.

Mild reinforcement learning deficits in patients with first-episode psychosis.
Chang WC, Waltz JA, Gold JM, Chan TCW, Chen EYH.
Schizophrenia Bulletin. 2016 Nov; 42(6):1476-1485.

Familial Alzheimer's disease-associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+ entry.
Tong BC, Lee CS, Cheng WH, Lai KO, Foskett JK, Cheung KH.
Sci Signal. 2016 Sep 6; 9(444):ra89.

Long-read sequencing and de novo assembly of a Chinese genome.
Shi L, Guo Y, Dong C, Huddleston J, Yang H, Han X, Fu A, Li Q, Li N, Gong S, Lintner KE, Ding Q, Wang Z, Hu J, Wang D, Wang F, Wang L, Lyon GJ, Guan Y, Shen Y, Evgrafov OV, Knowles JA, Thibaud-Nissen F, Schneider V, Yu CY, Zhou L, Eichler EE5, So KF, Wang K. 
Nat Commun. 2016 Jun 30; 7:12065.

Mild reinforcement learning deficits in patients with first-episode psychosis.  

Chang WC, Waltz JA, Gold JM, Chan TCW, Chen EYH.
Schizophrenia Bulletin, 2016 May 13. pii: sbw060.

The interaction of perceived control and gambler’s fallacy in risky decision making: An fMRI study.

Shao R, Sun D, Lee TMC.
Human Brain Mapping, 2016; 37: 1218-1234.

Loneliness in late-life depression: Structural and functional connectivity during affective processing.

Wong NML, Liu HL, Lin C, Huang CM, Wai YY, Lee SH, Lee TMC. 
Psychological Medicine, 2016 Jun 22:1-15.

H1 provides the missing link.  

Huen MS, Chen J.
Cell Res 2016; 26(1):5-6.

Optimal duration of an early intervention programme for first-episode psychosis: randomised controlled trial.

Chang WC, Chan GHK, Jim OTT, Lau ESK, Hui CLM, Chan SKW, Lee EHM, Chen EYH. 
British Journal of Psychiatry. 2015; 206 (6):492-500.

10-year outcome study of an early intervention program for psychosis compared with standard care service.

SKW Chan, HC So, CLM Hui, WC Chang, EHM Lee, DWS Chung, S Tso, SF Hung, KC Yip, E Dunn, EYH Chen.
Psychological Medicine, 2015; 45(6):1181-1193.

Delusional disorder and schizophrenia: a comparison of the neurocognitive and clinical characteristics in first-episode patients.

Hui CLM, Lee EHM, Chang WC, Chan SKW, Lin J, Xu Q, Chen EYH.
Psychological Medicine. 2015 Oct; 45(14):3085-95.

Diffusivity of the uncinate fasciculus in heroin users relates to their levels of anxiety.

Wong NML, Cheung S-H, Chan CCH, Zeng H, Li Y-P, So K-F, and Lee TMC.
Transl Psychiatry. 2015 Apr 28; 5:e554.

A pontine region is a neural correlate of the human affective processing network.

Lee TMC, Sun DL, Wong NML, Shao R, Men W, Ge J, So KF, Gao JH, Chan CCH.  
EbioMedicine, 2015 Oct 20;2(11):1799-1805.

Neural mediator of the schizotypy-antisocial behavior relationship.

Lam BYH, Yang Y, Raine A, Lee TMC.
Translational Psychiatry, 2015 Nov 3; 5:e669.

Dietary supplementation with n-3 fatty acids from weaning limits brain biochemistry and behavioural changes elicited by prenatal exposure to maternal inflammation in the mouse model.

Li Q, Leung YO, Zhou I, Ho LC, Kong W, Basil P, Wei R, Lam S, Zhang X, Law AC, Chua SE, Sham PC, Wu EX, McAlonan GM.
Translational Psychiatry, 2015 Sep 22; 5:e641. doi: 10.1038/tp.2015.126.

Local proliferation is the main source of rod microglia after optic nerve transection.

Yuan TF, Liang YX, Peng B, Lin B, So KF.
Scientific Reports 2015; 5, 10788.

Molecular architecture of the Ub-PCNA/Pol η complex bound to DNA.

Lau WC, Li Y, Zhang QF, Huen MS.
Sci Rep, 2015; 5:15759.

Can the neural–cortisol association be moderated by experience-induced changes in awareness?

Lau WKW, Leung MK, Chan CCH, Wong SSY, Lee TMC. 
Sci Rep, 2015 Nov 18; 5:16620.

Enhanced regeneration and functional recovery after spinal root avulsion by manipulation of the proteoglycan receptor PTPσ.

Li H, Wong C, Li W, Ruven C, He L, Wu X, Lang BT, Silver J, Wu W.
Sci Rep, 2015 Oct 14; 5:14923.

Increased co-expression of genes harboring the damaging de novo mutations in Chinese schizophrenic patients during prenatal development.

Wang Q, Li M, Yang Z, Hu X, Wu HM, Ni P, Ren H, Deng W, Li M, Ma X, Guo W, Zhao L, Wang Y, Xiang B, Lei W, Sham PC, Li T.
Sci Rep, 2015 Dec 15; 5:18209.

PKR deficiency alters E. coli-induced sickness behaviors but does not exacerbate neuroimmune responses or bacterial load.

Poon DCH, Ho YS, You R, Tse J, Chu K and Chang RCC. 
J Neuroinflamm, 2015; 12:212.

Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin.

Yau SY, Li A, Hoo RL, Ching YP, Christie BR, Lee TM, Xu A, So KF.
Proc Natl Acad Sci U S A. 2014 Oct 20. pii: 201415219.

Statistical power and significance testing in large-scale genetic studies.
Sham PC, Purcell SM.
Nat Rev Genet. 2014 May; 15(5):335-46.

Neurogenesis in neurological and psychiatric diseases and brain injury: From bench to bedside.
Ruan L, Lau BW, Wang J, Huang L, Zhuge Q, Wang B, Jin K, So KF.
Prog Neurobiol, 2014 Apr; 115:116-37.

Neuropathology of cigarette smoking.
Chang RCC, Ho YS, Wong S, Gentleman SM, Ng HK.
Acta Neuropathol, 127, 53-69.

Common variants on Xq28 conferring risk of schizophrenia in Han Chinese.
Wong EH, So HC, Li M, Wang Q, Butler AW, Paul B, Wu HM, Hui TC, Choi SC, So MT, Garcia-Barcelo MM, McAlonan GM, Chen EY, Cheung EF, Chan RC, Purcell SM, Cherny SS, Chen RR, Li T, Sham PC.
Schizophr Bull. 2014 Jul; 40(4):777-86.     

Peng B, Xiao J, Wang K, So KF, Tipoe GL, Lin B.

Sy SM, Jiang J, O WS, Deng Y, Huen MS. (2013). 
Nucleic Acids Res. 2013, 41(18):8572-80.

Tan LH, Xu M, Chang CQ, Siok WT.
Proc Natl Acad Sci U S A, 2013,110(3):1119-23.

Direct Retino-Raphe Projection Alters Serotonergic Tone and Affective Behavior.
Ren C, Luan L, Wui-Man Lau B, Huang X, Yang J, Zhou Y, Wu X, Gao J, Pickard GE, So KF, Pu M.
Neuropsychopharmacology, 2013, 1–13.

Predicting mendelian disease-causing non-synonymous single nucleotide variants in exome sequencing studies.
Li MX, Kwan JS, Bao SY, Yang W, Ho SL, Song YQ, Sham PC.
PLoS Genet. 2013 Jan;9(1):e1003143.

Two-stage genome-wide association study identifies variants in CAMSAP1L1 as susceptibility loci for epilepsy in chinese
Guo Y, Baum LW, Sham PC, Wong V, Ng PW, Lui CH, Sin NC, Tsoi TH, Tang CS, Kwan JS, Yip BH, Xiao SM, Thomas GN, Lau YL, Yang W, Cherny SS, Kwan P.
Human Molecular Genetics, 2012, 21(5), 1184-1189.

A comprehensive framework for prioritizing variants in exome sequencing studies of Mendelian diseases.
Li MX, Gui HS, Kwan JS, Bao SY, Sham PC.
Nucleic Acids Res. 2012 Apr;40(7):e53.

HYST: a hybrid set-based test for genome-wide association studies, with application to protein-protein interaction-based association analysis.
Li MX, Kwan JS, Sham PC.
Am J Hum Genet. 2012 Sep 7;91(3):478-88.

GATES: A Rapid and Powerful Gene-Based Association Test Using Extended Simes Procedure. 
Li MX, Gui HS, Kwan JS, Sham PC.
Am J Hum Genet. 2011, 88(3):283-293.

Risk prediction of complex diseases from family history and known susceptibility loci, with applications for cancer screening.
So HC, Kwan JS, Cherny SS, Sham PC.
Am J Hum Genet. 2011, 88(5):548-565.

Learning new color names produces rapid increase in gray matter in the intact adult human cortex. 
Kwok V, Niu Z, Kay P, Zhou K, Mo L, Jin Z, So KF, Tan LH.
Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6686-6688.

Electrophysiological evidence for the left-lateralized effect of language on preattentive categorical perception of color. 
Mo L, Xu G, Kay P, Tan LH.
Proc Natl Acad Sci USA. 2011 Aug 23;108(34):14026-14030.

Activity levels in the left hemisphere caudate-fusiform circuit predict how well a second language will be learned. 
Tan LH, Chen L, Yip V, Chan AH, Yang J, Gao JH, Siok WT.
Proc Natl Acad Sci U S A. 2011 Feb 8; 108(6):2540-2544.

Gray Matter in First-Episode Schizophrenia Before and After Antipsychotic Drug Treatment. Anatomical Likelihood Estimation Meta-analyses With Sample Size Weighting.
Leung M, Cheung C, Yu K, Yip B, Sham P, Li Q, Chua S, McAlonan G. 
Schizophr Bull. 2011 Jan;37(1):199-211.